Vol. 7, Issue 2, Part I (2025)

In the study, Carissa carandas leaves extract which was prepared in order to investigate the anti-peptic ulcer activity utilising model of peptic ulcers caused by NSAID induced peptic ulcer rat model method in Wistar rats. To the extract, HPLC & preliminary phytochemical screening were used. Wistar rats were orally administered extract & investigated for gastroprotective effect on peptic ulcer & compared their effect together with the usual medication (Ranitidine 50 milligrams per kilogram p.o..) of peptic ulcer prevention. Various parameters were measured including UI, GV, FA, TA & pH. After complete the procedure animals were sacrificed with the help of cervical dislocation method & the histopathological analysis of stomach tissue was investigated. The study demonstrates the role of the leaves of the Carissa carandas plant play in the entire model for anti-peptic ulcer activity. The extracts appear to hold promise for the creation of phytomedicine with anti-peptic ulcer effects & the study provides the way for further investigation into the elements of the extracts that mediate peptic ulcer prevention.