Vol. 7, Issue 2, Part H (2025)

Objective: The study focused on evaluating the anticonvulsant effects of Crassula ovata extract in various seizure models, including PTZ-induced epilepsy, MES (Maximal Electroshock) test, and Kainic acid-induced status epilepticus.

Material and Method: The leaves of Crassula ovata were collected from a succulent from Botanical Garden of Chhatarpur. The following chemicals were used in this study and are of analytical grade, procured from Sigma-Aldrich. The extraction of bioactive compounds was carried out using the Soxhlet apparatus. The Crassula ovata extract was administered to the animals either orally at varying doses of 100, 200, and 400 mg/kg. Standard antiepileptic drugs, such as diazepam and phenytoin, were used as positive controls, and the vehicle was administered to the control groups to evaluate the comparative efficacy of the extract

Results: The total phenolic content (TPC) was found to be highly abundant (+++), indicating a significant presence of phenolic compounds in the extract, which are often associated with antioxidant properties. The PTZ-induced seizure model was used to evaluate the anticonvulsant effects of Crassula ovata extract. The results indicated that Crassula ovata extract significantly delayed seizure onset and reduced seizure severity and duration at doses of 100 mg/kg and 200 mg/kg, suggesting that the extract possesses moderate anticonvulsant activityIn the MES (Maximal Electroshock) test, Diazepam and Phenytoin exhibited potent anticonvulsant effects by delaying seizure onset, reducing seizure severity, and shortening tonic hindlimb extension duration. Crassula ovata extract, particularly at 100 mg/kg and 200 mg/kg, also showed significant reductions in seizure parameters, but the effects were less pronounced compared to the positive controls

Conclusion: The study focused on evaluating the anticonvulsant effects of Crassula ovata extract in various seizure models, including PTZ-induced epilepsy, MES (Maximal Electroshock) test, and Kainic acid-induced status epilepticus. The results from these models indicated that Crassula ovata extract exhibited moderate anticonvulsant effects, particularly at lower doses of 100 mg/kg and 200 mg/kg.