Vol. 7, Issue 2, Part H (2025)

Snakebite remains a significant public health concern, particularly in rural regions where access to timely medical care and antivenom is limited. Andrographis paniculata, a traditionally valued medicinal herb, has gained attention for its potential supportive role in snakebite management. Its major constituents are especially andrographolide, exhibit anti-inflammatory, antioxidant, and enzyme-inhibitory activities that may counteract venom-induced tissue damage. Experimental evidence from in vitro and in vivo studies demonstrates its ability to inhibit key venom enzymes, reduce local inflammation, and protect organs from oxidative stress. While extracts show activity against venoms of species such as Naja naja and Daboia russelii, their efficacy remains partial and inconsistent. Limitations include variable extract quality, low bioavailability, rapid metabolism, and lack of clinical trials. Although A. paniculata shows promise as a complementary therapy, standardised formulations and human studies are essential before it can be considered a reliable adjunct in snakebite treatment.