Vol. 7, Issue 2, Part G (2025)

Pyoderma gangrenosum is an uncommon condition that affects both men and women of all ages, however it is more frequent in people over 50. It is typically related with an inside illness or condition. Its recognized associations include Inflammatory bowel illness (ulcerative colitis, Crohn's disease), Rheumatoid arthritis, myeloid blood dyscrasias, including leukaemia, Monoclonal Gammopathy (typically IgA), Chronic active hepatitis.
Granulomatosis and polyangiitis, PAPA Syndrome, Behçet's disease and other various less common relationships. Treatment for PG typically begins with fast-acting immunosuppressive drugs (corticosteroids and/or cyclosporine) to reduce inflammation, followed by the addition of more slowly acting immunosuppressive drugs with better adverse event profiles, such as biologics. Appropriate wound care is also necessary. Future research should concentrate on PG-specific outcome metrics and PG quality-of-life assessments. Despite the fact that PG is a well-known illness, early diagnosis is frequently overlooked. All doctors should be aware of this syndrome and actively evaluate PG when examining patients with ulcers, since effective and timely therapy at an early stage of the disease can minimize the risks of extended systemic treatment, delayed wound healing, and scarring.