Vol. 7, Issue 2, Part F (2025)

A crippling ailment, sciatica pain is typically brought on by irritation or compression of the sciatic nerve's roots in the lumbar spine. It manifests as intense, shooting pain along the sciatic nerve. Currently available treatments for sciatica pain include surgery, physical therapy, painkillers, and nonsteroidal anti-inflammatory medications (NSAIDs). These medications could, however, have drawbacks, such as inconsistent results and adverse effects. The night-flowering jasmine, or parijat (Nyctanthes arbor-tristis), is a medicinal plant that has long been utilized in Ayurveda for its analgesic and anti-inflammatory qualities. The purpose of this study is to provide an overview of the body of research and assess Parijat's possible analgesic benefits for treating sciatica pain. To find pertinent research on Parijat's analgesic effects in sciatica pain, a thorough search of internet databases was carried out. Numerous preclinical and clinical studies assessing Parijat's effectiveness and mechanisms of action in the treatment of pain were found throughout the search. Preclinical research has demonstrated that parijat extracts' ability to suppress inflammatory mediators and modify pain pathways confers analgesic effects. Bioactive substances such phenolic compounds, flavonoids, and iridoids have been linked to these effects. Parijat has also demonstrated anti-inflammatory properties by preventing the activation of the NF-κB signaling pathway and reducing the synthesis of pro-inflammatory cytokines. There are few clinical trials examining Parijat's effectiveness in treating sciatica pain. Preliminary data, however, indicates that Parijat preparations including topical and oral formulations may help individuals with sciatica achieve better functional results and alleviate their symptoms. Its analgesic, anti-inflammatory, and muscle relaxant qualities may be responsible for these effects. While the information that is now available is encouraging, more well planned, randomized controlled studies are required to determine Parijat's effectiveness, ideal dose, and long-term safety profile in the treatment of sciatica pain. Further research on the mechanisms of action and possible drug interactions is necessary. In summary, parijat may be used as an additional or alternative treatment for sciatica pain. Preclinical study has demonstrated its analgesic and anti-inflammatory qualities, which point to a viable direction for future investigation. But further clinical data is needed to confirm its effectiveness and safety in treating sciatica pain.