Vol. 7, Issue 2, Part F (2025)

Lagenaria siceraria is a medicinal plant with history of therapeutic use in traditional medicine. The main aim of the present study was to evaluate the invitro antioxidant and possible diuretic and anti urolithiatic activities of ethanolic seed extract of Lagenaria siceraria on albino rats. The invitro antioxidant activity was performed using standard methods such as DPPH and Hydroxyl scavenging assay. The diuretic activity in albino rats was assessed by measuring the urine volume and electrolytes excretion with oral administration of seed extract at doses of 150 mg/kg and 300 mg/kg body weight. And the results so obtained were compared with standard drug Furosemide (5mg/kg) body weight. Further the anti urolithiatic activity was assessed using ethylene glycol induced urolithiasis model. The various different parameters such as urine volume, calcium oxalate, phosphate, creatinine and uric acid levels were also analyzed using biochemistry analyzer. The histopathological examination of kidney was also performed to evaluate the crystal deposition and tissue architecture.