Vol. 7, Issue 2, Part E (2025)

Gastrointestinal (GI) disorders, Including Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), and functional dyspepsia, pose major global health challenges due to their chronic nature and significant impact on quality of life. Conventional pharmacological therapies such as proton pump inhibitors, corticosteroids, and biologics are effective but often limited by side effects, drug resistance, and incomplete symptom control. Increasing evidence supports the integration of natural products, particularly plant-derived compounds like curcumin, berberine, and flavonoids, into GI disorder management. These natural compounds exhibit potent anti-inflammatory, antioxidant, antimicrobial, and gut microbiota-modulating effects, offering complementary benefits alongside conventional treatments. Mechanistically, they regulate immune responses, enhance mucosal healing, improve gut motility, and restore microbial balance. Integrative approaches combining natural and modern therapies demonstrate synergistic effects, reducing drug dosage and improving therapeutic outcomes. However, safety, standardization, and regulatory challenges remain critical for clinical application. Future research focusing on personalized medicine, pharmacokinetics, and advanced formulations may enhance the efficacy and safety of these compounds.