Vol. 7, Issue 2, Part E (2025)

Monosodium glutamate (MSG), a widely used flavor enhancer, has raised concerns about potential neurobehavioral impairments, especially with chronic exposure. This study examines the effects of chronic MSG administration on anxiety-like behaviors using the light-dark adaptation test and motor coordination with the tight rope suspension test in Swiss albino mice. Forty male mice were divided into four groups and received MSG (40, 60, or 80 mg/kg) intraperitoneally for 90 days. Results showed dose-dependent anxiety and motor impairments, suggesting that MSG may interfere with emotional and motor functions. These findings underline the importance of regulating long-term dietary MSG intake.