Vol. 7, Issue 2, Part D (2025)

A 78-year-old male with Type 2 Diabetes Mellitus (T2DM) and Systemic Hypertension (SHTN) presented with bilateral diabetic foot ulcers, sepsis, and left foot gas gangrene. He was treated with intravenous meropenem and metronidazole, later followed by cefoperazone-sulbactam. During treatment, he developed tremors, insomnia, anorexia, and dry mouth. Serial laboratory monitoring showed resolution of leukocytosis and persistent anemia. The adverse effects were suspected to be related to prolonged antibiotic therapy. This case highlights the importance of monitoring for drug-induced toxicities, especially in the geriatric population.