Vol. 7, Issue 2, Part C (2025)

This study was carried out to evaluate the effect of Tribulus terrestris methanolic extract of leaf for analgesic activity by using eddy’s hot plate method. Here the extract group and control group animals were six which shows the different responses like 2 sec, 5 sec, 6 sec 7 sec at different time intervals like 0 min, 15min, 30 min, 60 min and 90 min etc. are recorded and observed the a response by avoiding the injury to the paws. The standard drug collected is diclofenac sodium 25mg of 5ml with calculated quality. Selected animals are albino mice having10mg/kg/body weight. Six animals are selected. Take the standard drug diclofenac sodium and calculate respectively depending upon the body weight of animals and standard drug is also taken as such the calculated dose. Observe the basal reactions of standard drug at different time intervals of 0, 15, 30, 60, and 90 min in each animal. Observe the paw licking or jumping response according to the time intervals given we observe the jumping response of the mice in sec i.e 3, 5,8,9,10,15 sec. The in-vivo analgesic activity was evaluated from methanolic extract of leaves of Tribulus terrestris in mice. The basal reaction response of control, standard and test animals were recorded in seconds, in which cut off period is 15 seconds, to avoid paw injury to the mice because eddys hot plate maintained at 55 °C temperature. The test samples were shown the significant analgesic activity when compared to the standard samples.