Vol. 7, Issue 2, Part B (2025)

Prurigo nodularis is an unusual chronic inflammatory skin disorder characterized by strongly pruritic, hyperkeratotic, and well-defined nodules on the extensor surfaces of the limbs and trunk. However the exact etiology was unknown, and it is often thought to be idiopathic. Histopathological examination of PN reveals hyperkeratosis, acanthosis, dermal fibrosis, and a mixed inflammatory infiltrate. However, atopic dermatitis (which affects up to 50% of people), chronic kidney failure, diabetes, hyperthyroidism, iron deficiency anaemia, hepatitis B and C, HIV, and blood malignancies are among the systemic, dermatological, infectious, and mental illnesses that have been connected to it. Managing prurigo nodularis is difficult, with patients often undergoing many therapy regimens that yield unsatisfactory outcomes. In this report, we describe the case of a 58-year-old male patient who has had prurigo nodularis for ten years. He tried topical and systemic anti-inflammatory and antihistamine medications but was still not relieved. A biopsy was performed, and the histological study revealed that the patient had prurigo nodularis.