Vol. 7, Issue 1, Part D (2025)

Non-alcoholic fatty liver disease (NAFLD) is a growing health concern characterized by excessive fat accumulation in liver cells, often progressing to non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Dietary factors play a crucial role in NAFLD development and progression. This review article provides a comprehensive overview of various dietary animal models used to study NAFLD, including high-fat diets, high-fructose diets, methionine-choline deficient diets, and atherogenic diets etc. These models replicate key features of human NAFLD, such as insulin resistance, oxidative stress, and inflammation, allowing researchers to investigate the underlying mechanisms and test potential therapeutic strategies. The review highlights the strengths and limitations of each model, discussing their relevance to human NAFLD and potential applications in preclinical research. By summarizing the current knowledge on dietary animal models of NAFLD, this review aims to facilitate the development of novel treatments for this disease and provide insights into the complex interactions between diet, metabolism, and liver disease.