Vol. 7, Issue 1, Part D (2025)

4D printing is the technique of producing 3D-printed objects with the capability to change gradually with respect to time in response to particular stimuli, such as exposure to air, water, or heat. A modification of 3D printing known as 4D printing uses specific materials, often known as "smart materials," that alter their morphology after printing in reaction to stimuli. The most frequent stimuli are pH, water, heat, wind, and other types of energy, depending on the usefulness of this technology. The advantage of 4D printing over 3D printing is that whereas 3D printed objects are often static, stiff, and lifeless, 4D printed structures are flexible, mobile, and capable of interacting with the environment depending on the stimuli. The potential for biomedical and bioengineering applications is enormous given that 4D printing has the capacity to convert 3D objects into smart structures in response to varied inputs. The ability of 4D printing in creating pre-programmed biomaterials that can go through transformations establishes new foundations for enabling smart pharmacology, tailored medicine, and smart drug administration, all of which can aid in battling illnesses in a better way. This review shows the potential of 4D printing to develop smart medication delivery, smart pharmacology, tailored drug administration, and greater patient compliance. This review outlines the most current developments in 4D printing's application to the healthcare industry as well as the many ways it is revolutionizing the development of personalized medicine and smart medication administration. It also underlined are the major advantages and limitations of this strategy.