Vol. 7, Issue 1, Part B (2025)

Transdermal drug delivery devices are used to administer medications topically. These are different-sized pharmacological preparations with one or more active components that are meant to be applied to intact skin to deliver the active ingredient after it has passed through the skin’s barriers. They do not include first-pass metabolism. Approximately 74% of medications taken orally nowadays do not work as intended. A transdermal drug delivery device was developed to increase efficacy. The regulated release of medication into the patient’s system is a significant benefit of transdermal drug delivery when compared to other techniques such as oral, topical, intravenous (IV), and intramuscular (IM) administration. Either a porous membrane containing a drug reservoir or the patient’s body heat melting small layers of medication incorporated in the adhesive are used to achieve this controlled release. Because of the skin’s strong barrier, transdermal medication administration has several drawbacks despite its advantages. Only tiny molecules can effectively penetrate the skin and be administered using this technique.