Vol. 7, Issue 1, Part A (2025)

Photopharmacology provides a novel method that utilizes light to alter the action of medicinal drugs. This study examines the principles governing the utilization of light in medication activation and deactivation, emphasizing molecular photoswitches and photo caging groups. The use of light modulation in medication design facilitates exact spatial and temporal manipulation of pharmacological effects, hence minimizing off-target activity and mitigating undesirable consequences. Recent breakthroughs have led to the discovery of novel chemicals that can be triggered by certain wavelengths, enabling focused therapy of illnesses including as cancer, neurological disorders, and inflammatory ailments. The study assesses advancements in the synthesis and utilization of photoswitchable molecules, the difficulties related to light transport in deep tissues, and the prospects for integrating photopharmacology with other innovative technologies in precision medicine. Additionally, the study examines preclinical and initial clinical studies that highlight the potential of light-controlled therapy. In conclusion, the study emphasizes future possibilities and the potential for photopharmacology to change drug delivery methods and therapeutic procedures, ultimately boosting treatment efficacy and patient safety.