Vol. 6, Issue 1, Part A (2024)

Bombay blood group is the most commonly asked rare blood in India. It is characterized by absence of normal ABH antigens and have been consistent with antibodies in serum. This blood group is suspected when reagent O cells show connection in reverse or back typing or during antibody screening. We present a case of Bombay phenotype which was at the beginning mistyped as O group. At the time of blood grouping, this blood group copy the O blood group due to the absence of H antigen, but it shows inability with O group blood during cross matching. Serum grouping or reverse grouping are necessary for confirmation of the diagnosis. Takes place due to point mutation of the H gene. If the patient bears two mutant gene (H gene), then it will result in Bombay or Oh phenotype. In the field of medical sciences, the Bombay blood group (oh/hh) is a rare develop entity. The blood group has recognizable genotype and phenotype characteristics. This article displays the dynamics involved in the Bombay blood group, presenting its epidemiology, phenotype, genotype, biochemistry distribution, clinical manifestations and management. Most of us are unknowing about such blood groups existence on planet. Bombay blood group is named so because the first case was launch in Bombay (now Mumbai) the financial capital of India. Bombay blood group is very small number of people’s people who not have antigen H in their blood and have antigen H as well as do not have B antigen.