Vol. 6, Issue 1, Part A (2024)

Background: The Peptic ulcer is an ulceration of the mucosa of GIT like lower esophagus, gastric, duodenal, in the jejunum mucosa, may be post-surgical anastomosis. The detection of Helicobacter pylori gived a fundamental re-evaluation way for the Causes and treatment of the Ulcer. The strongest evidence linked bacteria called H. pylori and peptic ulcer so that killing of infect bacteria effectively cured the disease and prevented ulcer recurrences.
Patients Method: A clinical study was performed in the especial surgical clinic -Kirkuk City, un 89 patients to observe with effectiveness of triple and quadruple combination drugs therapy. Healing ulcer confirm by the Endoscopic and Urease Test, then a post eradiction follow-up study was performed for two years, on sixty nine (69) and sixty five (65) of the treated patients respectively. The endoscopy and Urea breath test were carried out to demonstrate the recurrence rate of peptic ulcer. The questionnaire was done include data like patient age, smoking habit, state of stress, drug intake (NSAIDs and any drug for ulcer). The patients with recurrence were again treated by using (Triple eradication therapy) and to be also follow up. 
Results: Overall rate of recurrence in the first year follow up was 9 of 63 (14.28%), while the recurrence in the second year follow up was 13 of 65 (20.00%). The recurrence was occurred in 19.5% and 37.9% of smokers in the first and second years follow up respectively. On the other hand, recurrence was occurred in 1.9% and 5.5% of nonsmokers. Recurrence of peptic ulcer was also occurred more significantly (14.28 and 25%) after one and two years follow up respectively, in patients used NSAIDs compared with non ulcers. Recurrence was recorded more significantly 23.07% and 22.2% after one and two years follow up respectively, among patients with gastric ulcer compared with those with duodenal ulcer (7.5 and 19.64%). Recurrence showed significantly more rate 18.6 and 37.03% in the first and second years follow up respectively, among patients under stress. Recurrence showed significantly more rate 18.6 and 37.03% in the first and second years follow up respectively, among patients under stress. 
Conclusion: More than one cause of Peptic Ulcer should be consider (Which is important in the end result of their treatment). Using of Non-Steroidal Anti-Inflammatory Drugs, The state of stress, smoking habit and ulceration Site a clear risk for result of peptic ulcer eradicational- therapy.