Vol. 5, Issue 1, Part A (2023)

The varicella-zoster virus (VZV), which causes chickenpox or varicella, is a contagious illness. The virus is in charge of causing chickenpox. Anywhere in the world, sneezing, coughing, and direct skin contact with lesions can spread the chickenpox virus. It may start to spread one to two days before the rash manifests and continue to do so until all lesions have crusted over. Those who are not immune can contract chickenpox from shingles sufferers through touch with their blisters. The disease is recognized based on the symptoms that are now present, and the diagnosis is then confirmed by polymerase chain reaction (PCR) testing of the blister fluid or scabs. In India, chickenpox is among the most commonly neglected diseases. Chickenpox is more common in children and those with weakened immune systems. There are complications as a result. In 1990, there were recorded 11,200 deaths from chickenpox worldwide, and 6,800 in 2010. The virus may remain dormant in the ganglion and reactivate as a result of ageing, immunity (acquired, inherited, or iatrogenic), and other factors. Falling cellular immunity is one of the main causes of zoster, which can occur for a variety of reasons. In this review study, the pathophysiology, aetiology, symptoms, and combined therapy of chickenpox are discussed.