Contact: +91-9711224068
  • Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
International Journal of Pharmacology and Clinical Research

Vol. 2, Issue 1, Part A (2020)

Comparative study of effect of ranitidine and sitagliptin on healing of acetic acid induced gastric ulcer in rats

Author(s):

Amina Unis, Eman Abdelzaher

Abstract:

Gastric ulcer healing is a complex process that is regulated by several promoting factors including Cyclooxygenase-2 (COX-2) and Inducible Nitric Oxide Synthase (iNOS). Diabetes mellitus is usually associated with delayed gastric ulcer healing. Hence, the current study was designed to compare the effect of sitagliptin (dipeptidyl peptidase-4 inhibitor) with ranitidine on gastric ulcer healing. The present study was conducted on 40 male albino rats that were divided into four equal groups: Group 1: normal control group, group 2: gastric ulcer model, Group 3: sitagliptin treated group, Group 4: ranitidine treated group. Rats were sacrificed ten days after ulcer induction and stomach was removed for histopathological examination and Immuno histochemical evaluation of COX-2 and iNOS. This study revealed that gastric ulcer healing was significantly impaired in the sitagliptin-treated group when compared with ranitidine treated group, evidenced by histopathological examination of stomach showing significantly larger ulcerated area and ulcer base maturation impairment.COX-2 and iNOS expression as well as mean vascular density (MVD) were significantly diminished in the sitagliptin-treated group as compared to ulcer model group as well as ranitidine treated group. A significant positive correlation was found between COX-2 and iNOS implying their synergistic action. A significant positive correlation was found between MVD on one hand and COX-2 and iNOS on the other hand pointing to their proangiogenic effect. This results raise the question of whether sitagliptin is advisable in diabetic patients with pre-existing gastric ulcer. Our preliminary experimental findings need to be substantiated by future human studies.

Pages: 01-08  |  1232 Views  574 Downloads


International Journal of Pharmacology and Clinical Research
How to cite this article:
Amina Unis, Eman Abdelzaher. Comparative study of effect of ranitidine and sitagliptin on healing of acetic acid induced gastric ulcer in rats. Int. J. Pharmacol. Clin. Res. 2020;2(1):01-08. DOI: 10.33545/26647613.2020.v2.i1a.9
Call for book chapter