Grape Fruits contain a broad spectrum of nutrients, and many of which have antioxidant properties. Phenolic substances, vitamin A, vitamin C and minerals that are present in fruits displayed high antioxidant activity. These properties have been associated with the decreased risk of certain degenerative diseases. Grapes are known as the “Queen of fruits” contains a wide array of phenolic substances, has been reported to possess substantial anti-inflammatory properties. Resveratrol (trans-3, 4’, 5-trihydroxystilbene), a natural polyphenolic, non-flavonoid antioxidant, is a phytoalexin found in grapes have been documented for various health benefits, such as anti-inflammatory, antioxidant, antitumour and immunomodulatory activities. In the present study pharmacognostic standardization of Vitis vinifera is done.